Mesenchymal stem cell therapy for refractory scleroderma: a report of 2 cases
Abstract:
We treated 2 patients with progressive, refractory scleroderma with a combined immunotherapy approach using plasmapheresis followed by rituximab and then intravenous umbilical-cord-derived allogeneic mesenchymal stem cells (MSCs). Both patients improved subjectively and objectively for over a year. Upon recurrence of their symptoms, the patients were treated again with allogeneic MSCs alone with a very good
response. The combination was well tolerated and effective suggesting a large scale study may be warranted
in progressive, refractory Scleroderma.
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